ADCE-D01 uPARAP
uPARAP –the first potential pan-sarcoma ADC target
Target Biology Summary
- Constitutively cycling cell membrane receptor; Fast internalization of ligands/cargo within minutes post binding; Binds and internalizes collagen fragments and contributes to tissue homeostasis incl. wound healing and immune cell trafficking;
- Strong overexpression in mesenchymal tumors such as Soft-Tissue Sarcoma, Bone Sarcoma, GIST
- Overexpression in cancer-associated-fibroblasts (CAFs) in stroma of epithelial tumors