ADCE-T02 is a next generation ADC that combines an optimized Tissue Factor (TF) targeting monoclonal antibody with a next generation linker and exatecan payload technology, aiming to deliver strong anti-tumor activity with improved tolerability, potentially enabling long term use and future combination treatments.

TF is a clinically validated ADC target overexpressed in numerous solid tumor indications and associated with poor prognosis. Unlike the first-generation TF targeting ADC, ADCE-T02 has been optimized to avoid interference with the coagulation pathway and deliver a potent exatecan payload using an optimized hydrophilic, cleavable linker. ADCE-T02 has demonstrated strong anti-tumor activity in in vivo studies across a range of solid tumors with both high and low TF expression as well as excellent tolerability in toxicity studies. The combination of an optimized monoclonal antibody with a clinically validated topoisomerase I based linker-payload technology makes ADCE-T02 a promising candidate for improving cancer treatment outcomes over existing options.

ADCE-T02 is being investigated in a multicenter Phase I study (NCT06597721) that aims to assess its safety, tolerability, and optimal dose selection in patients with advanced cancers at clinical trial sites across the United States and Australia.

Enrolment is ongoing in the cohort expansion portion of the Tiffany-01 study across multiple solid tumor indications. The expansion cohorts are designed to evaluate two go-forward dose levels in a randomized setting, supporting dose optimization and enabling additional assessments of safety, anti-tumor activity, and durability of response. These data are expected to provide further clinical proof of concept and better inform the potential therapeutic profile of ADCE-T02 across multiple solid tumor indications.

ADCE-D01 is a novel ADC targeting uPARAP, an endocytic receptor overexpressed in a wide spectrum of cancers of mesenchymal origin, including soft tissue sarcoma (STS), osteosarcoma, GIST, mesothelioma, and glioblastoma.

uPARAP is an attractive ADC target due to its rapid internalization driven by constitutive recycling, as well as its highly differentiated expression profile between tumor and healthy tissues. ADCE-D01 combines a novel uPARAP binding antibody designed to avoid interference with the natural receptor ligand, collagen, with a clinically validated protease-cleavable linker and potent deruxtecan payload. Preclinical studies have demonstrated strong anti-tumor activity across a range of in vivo models, as well as a highly encouraging toxicology profile, positioning ADCE-D01 as a promising treatment candidate for patients with STS and other cancers of mesenchymal origin, with the potential to deliver meaningful clinical benefit.

ADCE-D01 is being investigated in a multicenter Phase I/II study (NCT06797999), ADCElerate1, to assess its safety, tolerability, and optimal dose selection in patients with soft tissue sarcoma at clinical trial sites across the United States and Europe.

ADCE-D01 received Fast Track Designation and Orphan Drug Designation (ODD) from the U.S. FDA for the treatment of soft tissue sarcoma.

ADCE-B05 is a novel ADC (target undisclosed) using a clinically validated linker-payload.

ADCE-B05 has demonstrated strong anti-tumor activity in multiple in vivo studies across a range of squamous cell tumors and exhibited excellent tolerability in pre-clinical toxicity studies.

ADCE-B05 is being investigated in a multicenter phase I study (NCT07362888), Galapagos 01, that aims to assess its safety, tolerability, and optimal dose selection in patients with advanced cancers at clinical trial sites across the United States and Australia.