ADCE-T02 TF
Tissue Factor (TF) – A highly attractive ADC target
Target Biology Summary
- Physiologically restricted to perivascular tissues
- Primary physiological initiator of coagulation
- Facilitates tumor growth, neo-angiogenesis, tumor invasion, and metastasis
- Overexpression in tumors due to hypoxia, loss of tumor suppressor genes (such as TP53 and PTEN), and overactivity of MAPK signaling.
