ADCE-T02 is a potential best-in-class ADC that combines an optimized Tissue Factor (TF) targeting monoclonal antibody with a next generation linker and exatecan payload technology, aiming to deliver better efficacy and improved tolerability.

TF is a clinically validated ADC target overexpressed in numerous solid tumor indications and associated with poor prognosis. Unlike the first-generation TF targeting ADC, ADCE-T02 has been optimized to avoid interference with the coagulation pathway and deliver a potent exatecan payload using an optimized hydrophilic, cleavable linker. ADCE-T02 has demonstrated strong anti-tumor activity in in vivo studies across a range of solid tumors with both high and low TF expression as well as excellent tolerability in toxicity studies. The combination of an optimized monoclonal antibody with a clinically validated topoisomerase I based linker-payload technology makes ADCE-T02 a promising candidate for improving cancer treatment outcomes over existing options.

ADCE-T02 is being investigated in a multicenter Phase I study (NCT06597721) that aims to assess its safety, tolerability, and optimal dose selection in patients with advanced cancers at clinical trial sites across the United States and Australia.

ADCE-D01 is a first-in-class ADC targeting uPARAP, an endocytic receptor overexpressed on a wide spectrum of cancers of mesenchymal origin, including soft tissue sarcomas, osteosarcoma, GIST, mesothelioma, and glioblastoma.

uPARAP is an ideal ADC target due to its rapid internalization and constitutive recycling, as well as its highly differentiated expression profile between tumor and healthy tissues. ADCE-D01 combines a uPARAP binding antibody designed to avoid interference with the natural receptor ligand, collagen, paired with a clinically validated protease-cleavable linker and potent deruxtecan payload. Preclinical studies have demonstrated strong anti-tumor activity across a range of in vivo models, as well as a highly encouraging toxicology profile, positioning ADCE-D01 as a potential first- and best-in-class ADC for patients with mesenchymal cancers of high unmet medical need.

ADCE-D01 is being investigated in a multicenter Phase I/II study (NCT06797999) to assess its safety, tolerability, and optimal dose selection in patients with patients with soft tissue sarcoma at clinical trial sites across the United States and Europe.