The collagen receptor


uPARAP is a collagen receptor which plays an important physiological role in collagen homeostasis by active internalization of collagen fragments. uPARAP displays highly efficient and constitutively active internalization and recycling properties


Extracellular collagen fibers are cleaved into smaller fragments by select matrix metalloproteases (MMPs)


Collagen fragments bind to endocytic receptor uPARAP on the cell surface


Collagen bound by uPARAP is actively endocytosed via clathrin-coated pits


uPARAP, and any bound collagen, is routed to early endosomes


uPARAP receptor is recycled to the cell surface for an additional internalization cycle


Collagen is further routed to lysosomes where is it broken down by proteases such as cathepsins

uPARAP displays a differentiated expression profile between healthy and cancer tissue, with several cancer types significantly overexpressing the receptor, including soft-tissue sarcoma, osteosarcoma, mesothelioma and glioblastoma multiforme (GBM).  

Additionally, uPARAP is found to be upregulated by cells in the stromal compartment in multiple indications, including breast-, colon-, pancreas- and prostate cancers. uPARAP is a recycling endocytic receptor with extremely rapid internalization kinetics, providing highly efficient entry for ADCs targeting uPARAP-expressing cells


Expression on tumor cells

  • Soft tissue sarcoma
  • Osteosarcoma
  • Mesothelioma
  • Glioblastoma

Total copy number in tumor cells

10,000 – 100,000

Expression on healthy tissue

Limited uPARAP expression in healthy tissues and in activated fibroblasts/myfibroblasts of surrounding stroma in certain tissues

High Internalization rate

Target and bound ligand internalization
within 5-10 minutes

Receptor recycling upon ligand binding and internalization


Adcendo has generated in-vivo proof of concept data with our lead uPARAP ADC asset in multiple target indications and with multiple payload MoAs.